HELPING THE OTHERS REALIZE THE ADVANTAGES OF NG 52

Investigations in to the mechanisms of action have shown that TAK-242 binds selectively to Cys747 inside the TIR domain of TLR4 [23] and subsequently disrupts the power of TLR4 to affiliate with TIRAP [24]. So far, TAK-242 is the one modest-molecule compound reported to control protein–protein interactions in between TLR4 and its adaptor molecule